Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations

Meiqi Han; Meiqi Han; Yu Wang; Yu Wang; Luyi Jing; Luyi Jing; Gucheng Yang; Gucheng Yang; Yaoyao Liu; Yaoyao Liu; Fan Mo; Fan Mo; Zhaojie Xu; Zhaojie Xu; Jinping Luo; Jinping Luo; Qianli Jia; Qianli Jia; Yuxin Zhu; Yuxin Zhu; Hanwen Cao; Hanwen Cao; Xinxia Cai; Xinxia Cai; Juntao Liu; Juntao Liu

doi:10.3389/fbioe.2024.1376151

Frontiers in Bioengineering and Biotechnology (Mar 2024)

Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations

Meiqi Han,
Meiqi Han,
Yu Wang,
Yu Wang,
Luyi Jing,
Luyi Jing,
Gucheng Yang,
Gucheng Yang,
Yaoyao Liu,
Yaoyao Liu,
Fan Mo,
Fan Mo,
Zhaojie Xu,
Zhaojie Xu,
Jinping Luo,
Jinping Luo,
Qianli Jia,
Qianli Jia,
Yuxin Zhu,
Yuxin Zhu,
Hanwen Cao,
Hanwen Cao,
Xinxia Cai,
Xinxia Cai,
Juntao Liu,
Juntao Liu

Affiliations

Meiqi Han: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Meiqi Han: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Yu Wang: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Yu Wang: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Luyi Jing: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Luyi Jing: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Gucheng Yang: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Gucheng Yang: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Yaoyao Liu: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Yaoyao Liu: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Fan Mo: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Fan Mo: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Zhaojie Xu: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Zhaojie Xu: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Jinping Luo: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Jinping Luo: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Qianli Jia: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Qianli Jia: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Yuxin Zhu: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Yuxin Zhu: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Hanwen Cao: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Hanwen Cao: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Xinxia Cai: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Xinxia Cai: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
Juntao Liu: State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
Juntao Liu: School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China

DOI: https://doi.org/10.3389/fbioe.2024.1376151
Journal volume & issue: Vol. 12

Abstract

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The striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of striatal electrophysiological activities in rats. These observations were made during and following seizure induction, particularly three and 7 days post-initial modeling. The modification of graphene oxide (GO)/poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)/platinu-m nanoparticles (PtNPs) demonstrated a marked reduction in impedance (10.5 ± 1.1 kΩ), and maintained exceptional stability, with impedance levels remaining consistently low (23 kΩ) even 14 days post-implantation. As seizure intensity escalated, we observed a corresponding increase in neuronal firing rates and local field potential power, with a notable shift towards higher frequency peaks and augmented inter-channel correlation. Significantly, during the grand mal seizures, theta and alpha bands became the dominant frequencies in the local field potential. Compared to the normal group, the spike firing rates on day 3 and 7 post-modeling were significantly higher, accompanied by a decreased firing interval. Power in both delta and theta bands exhibited an increasing trend, correlating with the duration of epilepsy. These findings offer valuable insights into the dynamic processes of striatal neural activity during the initial and latent phases of temporal lobe epilepsy and contribute to our understanding of the neural mechanisms underpinning epilepsy.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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