Nature Communications (Oct 2016)

Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments

  • Diana Fusco,
  • Matti Gralka,
  • Jona Kayser,
  • Alex Anderson,
  • Oskar Hallatschek

DOI
https://doi.org/10.1038/ncomms12760
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.