Nature Communications (Oct 2019)
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei
- Hao Chung The,
- Christine Boinett,
- Duy Pham Thanh,
- Claire Jenkins,
- Francois-Xavier Weill,
- Benjamin P. Howden,
- Mary Valcanis,
- Niall De Lappe,
- Martin Cormican,
- Sonam Wangchuk,
- Ladaporn Bodhidatta,
- Carl J. Mason,
- To Nguyen Thi Nguyen,
- Tuyen Ha Thanh,
- Vinh Phat Voong,
- Vu Thuy Duong,
- Phu Huong Lan Nguyen,
- Paul Turner,
- Ryan Wick,
- Pieter-Jan Ceyssens,
- Guy Thwaites,
- Kathryn E. Holt,
- Nicholas R. Thomson,
- Maia A. Rabaa,
- Stephen Baker
Affiliations
- Hao Chung The
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Christine Boinett
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Duy Pham Thanh
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Claire Jenkins
- Gastrointestinal Bacterial Reference Unit, National Infection Service, Public Health England
- Francois-Xavier Weill
- Institut Pasteur, Unité des Bactéries Pathogènes Entériques
- Benjamin P. Howden
- Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Mary Valcanis
- Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Niall De Lappe
- National Salmonella, Shigella, and Listeria monocytogenes Reference Laboratory, University Hospital Galway
- Martin Cormican
- School of Medicine, National University of Ireland Galway
- Sonam Wangchuk
- Public Health Laboratory, Department of Public Health, Ministry of Health, Royal Government of Bhutan
- Ladaporn Bodhidatta
- Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences
- Carl J. Mason
- Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences
- To Nguyen Thi Nguyen
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Tuyen Ha Thanh
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Vinh Phat Voong
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Vu Thuy Duong
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Phu Huong Lan Nguyen
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Paul Turner
- Centre for Tropical Medicine and Global Health, Oxford University
- Ryan Wick
- Department of Infectious Diseases, Central Clinical School, Monash University
- Pieter-Jan Ceyssens
- Unit Bacterial Diseases, Sciensano
- Guy Thwaites
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Kathryn E. Holt
- Department of Infectious Diseases, Central Clinical School, Monash University
- Nicholas R. Thomson
- London School of Hygiene and Tropical Medicine
- Maia A. Rabaa
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Stephen Baker
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- DOI
- https://doi.org/10.1038/s41467-019-12823-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Shigella sonnei is one of the main species causing shigellosis worldwide. Here the authors analyse nearly 400 S. sonnei genome sequences and carry out experimental evolution experiments to shed light into the evolutionary processes underlying the recent emergence of fluoroquinolone resistance in this pathogen.
