Diverse reactivity of the gem-difluorovinyl iodonium salt for direct incorporation of the difluoroethylene group into N- and O-nucleophiles

Abstract

The gem-difluoroethylene moiety is considered as a valuable building block in organic synthesis, but methods to introduce it into small molecules are generally limited to specific substrates. Here, the authors demonstrate that a gem-difluorovinyl iodonium salt enables the direct difluoroethylation reactions of a diverse range of N- and O-nucleophiles.