Guoji Yanke Zazhi (Oct 2018)

Changes of ocular related parameters in peri-hemodialysis in patients with end-stage diabetic nephropathy

  • En-Hui Yi,
  • Zhao-Jiang Du,
  • Jin-Gang He,
  • Ni-Na Li,
  • Yi Wang

DOI
https://doi.org/10.3980/j.issn.1672-5123.2018.10.47
Journal volume & issue
Vol. 18, no. 10
pp. 1940 – 1942

Abstract

Read online

AIM: To observe the changes of intraocular pressure(IOP), ocular perfusion pressure(OPP), central anterior chamber depth(CACD)and subfoveal choroidal thickness(SFCT)in peri-hemodialysis in patients with end-stage diabetic nephropathy(ESDN), for evaluating the influences of hemodialysis(HD)on ocular blood supply of the ESDN patients. METHODS: Totally 42 cases(84 eyes)of ESDN patients treated with HD in the Department of Nephrology were observed. Systolic and diastolic blood pressure, IOP with the hand-held rebound tonometer were measured at 30min before HD, 2h after HD duration and 30min after HD completion. OPP was calculated(OPP= 4/9 diastolic pressure + 2/9 systolic pressure - IOP). CACD measured by optical coherence measuring instrument(IOL-Master)and SFCT measured by optical coherence tomography(OCT)were observed at 30min before HD and 30min after HD completion. The outcomes were assessed by analysis of homogeneity test of variance, one-way ANOVA, LSD-t test and t-test, to look for differences of the parameters in various time of HD. RESULTS: Totally 84 eyes of ESDN patients: in 30min before HD, 2h after HD duration and 30min after HD completion, systolic blood pressure was no statistically significant(F=0.254, P=0.783), and diastolic blood pressure was no statistically significant(F=0.114, P=0.896), and IOP was statistically significant(F=7.527, P=0.001), and OPP was statistically significant(F=4.692, P=0.027). In 2h after HD duration and 30min after HD completion, IOP was statistically significant(t=-3.646, P=0.001), and OPP was statistically significant(t=2.321, P=0.022). In 30min before HD and 30min after HD completion, increase of IOP was statistically significant(t=-2.977, P=0.003), and OPP was no statistically significant(t=0.219, P=0.872), and decrease of CACD was statistically significant(t=6.291, Pt=5.736, PCONCLUSION: IOP increasing, OPP transiently decreasing, CACD shallow and SFCT thin were presented in peri-hemodialysis. It is important to evaluate eye conditions of ESDN patients before HD, and to take effective preventive measures to reduce the possible risk factors in peri-hemodialysis.

Keywords