Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
Won Jin Lee,
Gyeong Hee Lee,
Jinwoo Hur,
Hyuk Gyoon Lee,
Eunsu Kim,
Jun Pil Won,
Youngjae Cho,
Mi-Jung Choi,
Han Geuk Seo
Affiliations
Won Jin Lee
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Gyeong Hee Lee
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Jinwoo Hur
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Hyuk Gyoon Lee
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Eunsu Kim
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Jun Pil Won
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Youngjae Cho
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Mi-Jung Choi
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
Han Geuk Seo
Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea
This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage.
