Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Martin Vaeth; Yin-Hu Wang; Miriam Eckstein; Jun Yang; Gregg J. Silverman; Rodrigo S. Lacruz; Kasthuri Kannan; Stefan Feske

doi:10.1038/s41467-019-08959-8

Nature Communications (Mar 2019)

Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Martin Vaeth,
Yin-Hu Wang,
Miriam Eckstein,
Jun Yang,
Gregg J. Silverman,
Rodrigo S. Lacruz,
Kasthuri Kannan,
Stefan Feske

Affiliations

Martin Vaeth: Department of Pathology, New York University School of Medicine
Yin-Hu Wang: Department of Pathology, New York University School of Medicine
Miriam Eckstein: Department of Basic Science and Craniofacial Biology, New York University College of Dentistry
Jun Yang: Department of Pathology, New York University School of Medicine
Gregg J. Silverman: Department of Medicine, New York University School of Medicine
Rodrigo S. Lacruz: Department of Basic Science and Craniofacial Biology, New York University College of Dentistry
Kasthuri Kannan: Department of Pathology, New York University School of Medicine
Stefan Feske: Department of Pathology, New York University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-08959-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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