Терапевтический архив (May 2017)

Cancer-testis genes in colon cancer

  • N R Hilal,
  • D V Novikov,
  • V V Novikov,
  • A V Karaulov

DOI
https://doi.org/10.17116/terarkh2017895113-117
Journal volume & issue
Vol. 89, no. 5
pp. 113 – 117

Abstract

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The expression of cancer-testis (CT) genes varies with tumor type. There are tumors with high, low, and intermediate gene expressions. Tumor cells of different origin are characterized by ST gene co-expression. The expression of ST genes increases in later stages of tumor development in the presence of metastases. In colon cancer, the tumor samples showed most frequently MAGE-A and SSX mRNA. The peripheral blood samples displayed most commonly XAGE, MAGE-C, and SSX mRNA. In patients with colon cancer, the expression of TSP50, MAGE-A(1-6), and SSX1,2,4 genes was associated with a poor prognosis, that of MAGE-C1 and XAGE1 was related to a favorable prognosis.

Keywords