Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP

Abstract

Highlights Purkinje cell excitability dramatically increased after exposure to 3-AP. 3-AP caused a significant decrease in ISI, half-width, and first spike latency. CB1R antagonist attenuated the cellular effects of 3-AP. AM251 reduced the excitability of Purkinje cells exposed to 3-AP.

Keywords

• Ataxia
• Cerebellum
• Purkinje cell
• Cannabinoid
• CB1R