Nature Communications (Jan 2021)
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
- Xin Hu,
- Marcos R. Estecio,
- Runzhe Chen,
- Alexandre Reuben,
- Linghua Wang,
- Junya Fujimoto,
- Jian Carrot-Zhang,
- Nicholas McGranahan,
- Lisha Ying,
- Junya Fukuoka,
- Chi-Wan Chow,
- Hoa H. N. Pham,
- Myrna C. B. Godoy,
- Brett W. Carter,
- Carmen Behrens,
- Jianhua Zhang,
- Mara B. Antonoff,
- Boris Sepesi,
- Yue Lu,
- Harvey I. Pass,
- Humam Kadara,
- Paul Scheet,
- Ara A. Vaporciyan,
- John V. Heymach,
- Ignacio I. Wistuba,
- J. Jack Lee,
- P. Andrew Futreal,
- Dan Su,
- Jean-Pierre J. Issa,
- Jianjun Zhang
Affiliations
- Xin Hu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Marcos R. Estecio
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Runzhe Chen
- Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Alexandre Reuben
- Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Linghua Wang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Junya Fujimoto
- Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Jian Carrot-Zhang
- Broad Institute of MIT and Harvard
- Nicholas McGranahan
- Cancer Research United Kingdom-University College London Lung Cancer Centre of Excellence
- Lisha Ying
- Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences
- Junya Fukuoka
- Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences
- Chi-Wan Chow
- Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Hoa H. N. Pham
- Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences
- Myrna C. B. Godoy
- Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center
- Brett W. Carter
- Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center
- Carmen Behrens
- Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Mara B. Antonoff
- Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Boris Sepesi
- Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Yue Lu
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Harvey I. Pass
- Department of Cardiothoracic Surgery, New York University Langone Medical Center
- Humam Kadara
- Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Paul Scheet
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Ara A. Vaporciyan
- Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- John V. Heymach
- Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- J. Jack Lee
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Dan Su
- Department of Pathology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
- Jean-Pierre J. Issa
- Coriell Institute for Medical Research
- Jianjun Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-20907-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden and copy number alterations.
