Southern African Journal of HIV Medicine (Jun 2013)

Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update

  • The Southern African HIV Clinicians Society

DOI
https://doi.org/10.4102/sajhivmed.v14i2.82
Journal volume & issue
Vol. 14, no. 2
pp. 76 – 86

Abstract

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Six years after the first Society guidelines were published, cryptococcal meningitis (CM) remains an important cause of morbidity and mortality among HIV-infected adults in South Africa. Several important developments have spurred the publication of updated guidelines to manage this common fungal opportunistic infection. Recommendations described here include: (1) screening and pre-emptive treatment; (2) laboratory diagnosis and monitoring; (3) management of a first episode of CM; (4) amphotericin B deoxycholate toxicity prevention, monitoring and management; (5) timing of antiretroviral therapy among patients with CM; (6) management of raised intracranial pressure; (7) management of relapse episodes of CM.