Nature Communications (Aug 2020)

Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing

  • Minjoo Kim,
  • Nicholas J. Sisco,
  • Jacob K. Hilton,
  • Camila M. Montano,
  • Manuel A. Castro,
  • Brian R. Cherry,
  • Marcia Levitus,
  • Wade D. Van Horn

DOI
https://doi.org/10.1038/s41467-020-18026-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The TRPV1 ion channel is a heat-sensing receptor that is also activated by vanilloid compounds, but the molecular underpinnings of thermosensing have remained elusive. Here authors use in solution NMR on the isolated human TRPV1 S1-S4 domain and show that this domain undergoes a non-denaturing temperature-dependent transition with a high thermosensitivity.