Effect of MPV and β₂-microglobulin on cardiac valve calcification in patients on maintenance hemodialysis

Abstract

Objective To investigate the relationship between mean platelet volume （MPV） and β2-microglobulin and cardiac valve calcification （CVC） in maintenance hemodialysis patients， aiming to provide a basis for clinical prediction and diagnosis of CVC. Methods Seventy patients on regular hemodialysis were selected and divided into the non-CVC （n=36） and CVC groups （n=34） according to the presence or absence of CVC. Gender， age， dialysis age， blood phosphorus， blood calcium， parathyroid hormone， 25 hydroxy-vitamin D3， albumin， prealbumin， iron， unsaturated iron， transferrin， ferritin total iron binding capacity， alkaline phosphatase， lipids， β2-microglobulin， MPV and neutrophil-to-lymphocyte ratio （NLR） were statistically compared between two groups. The risk factors for the incidence of CVC were assessed by Logistic regression analysis. Results Compared with the non-CVC group， age， dialysis age， MPV， β2-microglobulin and NLR were significantly higher in the CVC group， and all differences were statistically significant （all P < 0.05）. Logistic regression analysis showed that age （OR = 1.101，P = 0.018）， MPV （OR = 2.894，P =0.003）， and β2-microglobulin （OR = 1.064，P = 0.038） were the independent risk factors for the incidence of CVC in maintenance hemodialysis patients. Conclusion MPV and β2-microglobulin are closely associated with the occurrence and development of CVC in maintenance hemodialysis patients， which are independent risk factors affecting CVC.

Keywords

• mean platelet volume|β₂-microglobulin|hemodialysis|valve calcification