Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours

Adama Sidibe; Patricia Ropraz; Stéphane Jemelin; Yalin Emre; Marine Poittevin; Marc Pocard; Paul F. Bradfield; Beat A. Imhof

doi:10.1038/s41467-017-02610-0

Nature Communications (Jan 2018)

Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours

Adama Sidibe,
Patricia Ropraz,
Stéphane Jemelin,
Yalin Emre,
Marine Poittevin,
Marc Pocard,
Paul F. Bradfield,
Beat A. Imhof

Affiliations

Adama Sidibe: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva
Patricia Ropraz: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva
Stéphane Jemelin: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva
Yalin Emre: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva
Marine Poittevin: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva
Marc Pocard: Department of Oncologic and Digestive Surgery, AP-HP, Hospital Lariboisière
Paul F. Bradfield: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva
Beat A. Imhof: Department of Pathology and Immunology, Centre Médical Universitaire (CMU), Medical faculty, University of Geneva

DOI: https://doi.org/10.1038/s41467-017-02610-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 19

Abstract

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Circulating myeloid cells can leave the vasculature to infiltrate tumours and are thought to contribute to tumour angiogenesis. Here the authors live image monocytes that migrate to xenograft tumours and map an extravasation cascade of human proangiogenic monocytes into the tumour.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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