Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Nir Lipsman; Ying Meng; Allison J. Bethune; Yuexi Huang; Benjamin Lam; Mario Masellis; Nathan Herrmann; Chinthaka Heyn; Isabelle Aubert; Alexandre Boutet; Gwenn S. Smith; Kullervo Hynynen; Sandra E. Black

doi:10.1038/s41467-018-04529-6

Nature Communications (Jul 2018)

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Nir Lipsman,
Ying Meng,
Allison J. Bethune,
Yuexi Huang,
Benjamin Lam,
Mario Masellis,
Nathan Herrmann,
Chinthaka Heyn,
Isabelle Aubert,
Alexandre Boutet,
Gwenn S. Smith,
Kullervo Hynynen,
Sandra E. Black

Affiliations

Nir Lipsman: Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto
Ying Meng: Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto
Allison J. Bethune: Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Yuexi Huang: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Benjamin Lam: Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Mario Masellis: Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Nathan Herrmann: Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Chinthaka Heyn: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Isabelle Aubert: Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Alexandre Boutet: Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto
Gwenn S. Smith: Department of Psychiatry and Behavioral Sciences and Radiology and Radiological Sciences, Johns Hopkins University
Kullervo Hynynen: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto
Sandra E. Black: Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto

DOI: https://doi.org/10.1038/s41467-018-04529-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Magnetic resonance-guided focused ultrasound with injected microbubbles has been used to temporarily open the blood–brain barrier (BBB) in animal models of Alzheimer's disease (AD). Here, the authors use this technology to non-invasively open the BBB in 5 patients with mild-to-moderate AD in a phase I trial, and show that the procedure is safe.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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