Frontiers in Psychiatry (Jun 2023)
Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
- Sarah E. Watling,
- Sarah E. Watling,
- Shawn G. Rhind,
- Shawn G. Rhind,
- Jerry Warsh,
- Jerry Warsh,
- Jerry Warsh,
- Jerry Warsh,
- Jerry Warsh,
- Duncan Green,
- Duncan Green,
- Tina McCluskey,
- Tina McCluskey,
- Junchao Tong,
- Junchao Tong,
- Junchao Tong,
- Peter Truong,
- Sofia Chavez,
- J. Don Richardson,
- J. Don Richardson,
- J. Don Richardson,
- J. Don Richardson,
- Stephen J. Kish,
- Stephen J. Kish,
- Stephen J. Kish,
- Stephen J. Kish,
- Stephen J. Kish,
- Isabelle Boileau,
- Isabelle Boileau,
- Isabelle Boileau,
- Isabelle Boileau
Affiliations
- Sarah E. Watling
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Sarah E. Watling
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Shawn G. Rhind
- Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada
- Shawn G. Rhind
- Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, Canada
- Jerry Warsh
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Jerry Warsh
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Jerry Warsh
- Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Jerry Warsh
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Jerry Warsh
- Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
- Duncan Green
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Duncan Green
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Tina McCluskey
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Tina McCluskey
- Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Junchao Tong
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Junchao Tong
- Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Junchao Tong
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Peter Truong
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Sofia Chavez
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- J. Don Richardson
- The MacDonald Franklin Operational Stress Injury (OSI) Research Centre, Lawson Health Research Institute, London, ON, Canada
- J. Don Richardson
- Department of Psychiatry, Western University, London, ON, Canada
- J. Don Richardson
- 0Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
- J. Don Richardson
- 1St. Joseph's London Operational Stress Injury (OSI), Parkwood Institute, St. Joseph's Health Care, London, ON, Canada
- Stephen J. Kish
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Stephen J. Kish
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Stephen J. Kish
- Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Stephen J. Kish
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Stephen J. Kish
- Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
- Isabelle Boileau
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Isabelle Boileau
- Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Isabelle Boileau
- Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
- Isabelle Boileau
- Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
- DOI
- https://doi.org/10.3389/fpsyt.2023.1195012
- Journal volume & issue
-
Vol. 14
Abstract
IntroductionOxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's most abundant antioxidant, in PTSD remains uncertain. Therefore, the current study investigated brain concentrations of GSH and peripheral concentrations of blood markers in individuals with PTSD vs. Healthy Controls (HC).MethodsGSH spectra was acquired in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) using MEGA-PRESS, a J-difference-editing acquisition method. Peripheral blood samples were analyzed for concentrations of metalloproteinase (MMP)-9, tissue inhibitors of MMP (TIMP)-1,2, and myeloperoxidase (MPO).ResultsThere was no difference in GSH between PTSD and HC in the ACC (n = 30 PTSD, n = 20 HC) or DLPFC (n = 14 PTSD, n = 18 HC). There were no group differences between peripheral blood markers (P > 0.3) except for (non-significantly) lower TIMP-2 in PTSD. Additionally, TIMP-2 and GSH in the ACC were positively related in those with PTSD. Finally, MPO and MMP-9 were negatively associated with duration of PTSD.ConclusionsWe do not report altered GSH concentrations in the ACC or DLPFC in PTSD, however, systemic MMPs and MPO might be implicated in central processes and progression of PTSD. Future research should investigate these relationships in larger sample sizes.
Keywords
- magnetic resonance spectroscopy
- glutathione
- metalloproteinase (MMP)
- myeloperoxidase (MPO)
- psychiatric disorder
- posttraumatic stress disorder (PTSD)
