Taxonomy Meets Neurology, the Case of Amyotrophic Lateral Sclerosis

Abstract

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Recent landmark publications from our research group outline a transformative approach to defining, studying and treating amyotrophic lateral sclerosis (ALS). Rather than approaching ALS as a single entity, we advocate targeting therapies to distinct “clusters” of patients based on their specific genomic and molecular features. Our findings point to the existence of a molecular taxonomy for ALS, bringing us a step closer to the establishment of a precision medicine approach in neurology practice.

Keywords

• ALS
• amyotrophic lateral sclerosis
• molecular taxonomy
• personalized medicine
• neurodegenerative disease
• multiomic analysis