Nature Communications (Oct 2022)

An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases

  • Ondřej Gahura,
  • Alexander Mühleip,
  • Carolina Hierro-Yap,
  • Brian Panicucci,
  • Minal Jain,
  • David Hollaus,
  • Martina Slapničková,
  • Alena Zíková,
  • Alexey Amunts

DOI
https://doi.org/10.1038/s41467-022-33588-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Mitochondrial ATP synthase assemble into oligomers. Here, authors resolve the structure of trypanosomal ATP synthase, showing that its dimerization is essential for function and evolutionary conserved.