Open Medicine (Jun 2024)

miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor

  • Jing Yanyan,
  • Qi Lei,
  • Zhang Xueli,
  • Zheng Lu,
  • Yang Peijin,
  • Yin Jie,
  • Shi Yugen,
  • Yan Suhua

DOI
https://doi.org/10.1515/med-2024-0975
Journal volume & issue
Vol. 19, no. 1
pp. ii14 – 8

Abstract

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Sympathetic hyperinnervation following myocardial infarction (MI) is one of the primary causes of ventricular arrhythmias (VAs) after MI. Nerve growth factor (NGF) is a key molecule that induces sympathetic nerve remodeling. Previous studies have confirmed that microRNA (miR)-let-7a interacts with NGF. However, whether miR-let-7a is involved in sympathetic remodeling after MI remains unknown. We aimed to investigate whether miR-let-7a was associated with the occurrence of VA after MI.

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