miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
Jing Yanyan,
Qi Lei,
Zhang Xueli,
Zheng Lu,
Yang Peijin,
Yin Jie,
Shi Yugen,
Yan Suhua
Affiliations
Jing Yanyan
Department of Cardiology, Yantai Yuhuangding Hospital, Shandong University, Yantai, China
Qi Lei
Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Zhang Xueli
Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Zheng Lu
Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Yang Peijin
Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Yin Jie
Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Shandong, 250014, China
Shi Yugen
Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Shandong, 250014, China
Yan Suhua
Department of Cardiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
Sympathetic hyperinnervation following myocardial infarction (MI) is one of the primary causes of ventricular arrhythmias (VAs) after MI. Nerve growth factor (NGF) is a key molecule that induces sympathetic nerve remodeling. Previous studies have confirmed that microRNA (miR)-let-7a interacts with NGF. However, whether miR-let-7a is involved in sympathetic remodeling after MI remains unknown. We aimed to investigate whether miR-let-7a was associated with the occurrence of VA after MI.