Study on synergistic action of Coriandrum sativum seed extracts on antibiotics against multidrug resistant P. aeruginosa

Abstract

Increase in resistance of antibiotic against P. aeruginosa, the antibiotic treatment therapy fail to exterminate the infection. The approach of new strategy is must to deal with multidrug resistant P. aeruginosa. In the present study total 300 isolates from different clinical samples (Urine, Blood, Sputum, and Pus) were studied for isolation, identification and analysis of resistance pattern against 22 antibiotics. Total 5 most resistant isolates (U004, P017, P078, U105, and U237) were screened to search for synergistic approach of Coriandrum sativum extract prepared by both Soxhlet method and Maceration process in different solvents; petroleum ether, chloroform, acetone, methanol and water. Encouraging results were obtained where HDME extract could synergise the activity of total 8 antibiotics that are; MZ, CPZ, CTX, PB, LE, DOR, AZ and CAZ. Thus the present study provides and landmark approach to deal with multidrug resistant P. aeruginosa by synergistic action of antibiotic and Coriandrum sativum extract.

Keywords

• Coriandrum sativum
• P. aeruginosa
• Multidrug resistant
• Synergistic action
• Antibiotics
• Solvents