Frontiers in Molecular Biosciences (May 2021)

Function of Non-coding RNA in Helicobacter pylori-Infected Gastric Cancer

  • Chao Wang,
  • Yiyang Hu,
  • Huan Yang,
  • Sumin Wang,
  • Bo Zhou,
  • Yulu Bao,
  • Yu Huang,
  • Qiang Luo,
  • Chuan Yang,
  • Xia Xie,
  • Shiming Yang

DOI
https://doi.org/10.3389/fmolb.2021.649105
Journal volume & issue
Vol. 8

Abstract

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Gastric cancer is a common malignant tumor of the digestive system. Its occurrence and development are the result of a combination of genetic, environmental, and microbial factors. Helicobacter pylori infection is a chronic infection that is closely related to the occurrence of gastric tumorigenesis. Non-coding RNA has been demonstrated to play a very important role in the organism, exerting a prominent role in the carcinogenesis, proliferation, apoptosis, invasion, metastasis, and chemoresistance of tumor progression. H. pylori infection affects the expression of non-coding RNA at multiple levels such as genetic polymorphisms and signaling pathways, thereby promoting or inhibiting tumor progression or chemoresistance. This paper mainly introduces the relationship between H. pylori-infected gastric cancer and non-coding RNA, providing a new perspective for gastric cancer treatment.

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