Nature Communications (Feb 2018)
Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
- Zhongfang Wang,
- Lingyan Zhu,
- Thi H. O. Nguyen,
- Yanmin Wan,
- Sneha Sant,
- Sergio M. Quiñones-Parra,
- Jeremy Chase Crawford,
- Auda A. Eltahla,
- Simone Rizzetto,
- Rowena A. Bull,
- Chenli Qiu,
- Marios Koutsakos,
- E. Bridie Clemens,
- Liyen Loh,
- Tianyue Chen,
- Lu Liu,
- Pengxing Cao,
- Yanqin Ren,
- Lukasz Kedzierski,
- Tom Kotsimbos,
- James M. McCaw,
- Nicole L. La Gruta,
- Stephen J. Turner,
- Allen C. Cheng,
- Fabio Luciani,
- Xiaoyan Zhang,
- Peter C. Doherty,
- Paul G. Thomas,
- Jianqing Xu,
- Katherine Kedzierska
Affiliations
- Zhongfang Wang
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Lingyan Zhu
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Thi H. O. Nguyen
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Yanmin Wan
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Sneha Sant
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Sergio M. Quiñones-Parra
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Jeremy Chase Crawford
- Department of Immunology, St. Jude Children’s Research Hospital
- Auda A. Eltahla
- School of Medical Sciences and The Kirby Institute, UNSW Sydney
- Simone Rizzetto
- School of Medical Sciences and The Kirby Institute, UNSW Sydney
- Rowena A. Bull
- School of Medical Sciences and The Kirby Institute, UNSW Sydney
- Chenli Qiu
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Marios Koutsakos
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- E. Bridie Clemens
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Liyen Loh
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Tianyue Chen
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Lu Liu
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Pengxing Cao
- School of Mathematics and Statistics, University of Melbourne
- Yanqin Ren
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Lukasz Kedzierski
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Tom Kotsimbos
- Department of Respiratory Medicine, Alfred Hospital Health and Department Medicine, Monash University
- James M. McCaw
- School of Mathematics and Statistics, University of Melbourne
- Nicole L. La Gruta
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Stephen J. Turner
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Allen C. Cheng
- Infection Prevention and Healthcare Epidemiology Unit, Alfred Health and School of Public Health and Preventive Medicine
- Fabio Luciani
- School of Medical Sciences and The Kirby Institute, UNSW Sydney
- Xiaoyan Zhang
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Peter C. Doherty
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Paul G. Thomas
- Department of Immunology, St. Jude Children’s Research Hospital
- Jianqing Xu
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- Katherine Kedzierska
- Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- DOI
- https://doi.org/10.1038/s41467-018-03243-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Virus-specific CD8+ T cells are crucial during H7N9 influenza infection, but CD8+ T cell dysfunction is associated with poor prognosis. Here, the authors use molecular and phenotypic analysis to establish persistence of clonally diverse CD8+ T cell populations during fatal infection.
