Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy

Despina Michailidou; Daniella Muallem Schwartz; Tomas Mustelin; Grant C. Hughes

doi:10.3389/fimmu.2021.693192

Frontiers in Immunology (Jul 2021)

Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy

Despina Michailidou,
Daniella Muallem Schwartz,
Tomas Mustelin,
Grant C. Hughes

Affiliations

Despina Michailidou: Division of Rheumatology, University of Washington, Seattle, WA, United States
Daniella Muallem Schwartz: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Tomas Mustelin: Division of Rheumatology, University of Washington, Seattle, WA, United States
Grant C. Hughes: Division of Rheumatology, University of Washington, Seattle, WA, United States

DOI: https://doi.org/10.3389/fimmu.2021.693192
Journal volume & issue: Vol. 12

Abstract

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IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell (Treg) activation, IgG4 and IgE hypersecretion, and blood/tissue eosinophilia. In addition, IgG4-RD tissue fibrosis appears to involve activation of basophils and mast cells and their release of alarmins and cytokines. In this article, we review allergy-like features of IgG4-RD and highlight targeted therapies for allergy that have potential in treating patients with IgG4-RD.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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