Hormonal changes aggravate premenstrual tension syndrome in obese women and beneficial roles of combined pharmacological therapies: A randomized controlled trial

Abstract

Background: The recurring psychological, behavioural, and physical symptoms of premenstrual tension syndrome (PTS) are related to the luteal phase of the menstrual cycle. Its development may be influenced by hormonal influences. Objectives: To investigate the effects of catecholamines on PTS and possible improvements upon using pharmacological treatments. Patients and methods: After agreement of participants and ethical committee approval, this randomized controlled trial enrolled 60 obese women with PTS who were split into younger (18-39 years) and older (40-48 years) age groups in comparison to an age-matched healthy control group. All of the study participants' serum levels of adrenaline (epinephrine), and norepinephrine were measured. Utilizing pertinent rating scales, a few psychosomatic PTS symptoms (headache, backache, and stomach bloating) were also assessed. Results: Compared to the control group, obese women with PTS had significantly higher serum levels of adrenaline, and noradrenaline (p<0.05). Utilizing a combination of therapies, including Metformin, Amiloride/ Hydrochlorthiazide, a calorie-restricted diet, walking exercises, and either Vitazinc®, or Royal vitamin G, significantly (p< 0.01) reduced the hormonal abnormalities. In women with PTS, symptoms of headache, backache, and stomach bloating significantly increased (p< 0.001). Utilizing the combined treatments dramatically improved all of that. In conjunction with the normalization of serum hormone levels, such combined therapies considerably reduced the levels of the aforementioned hormones in the blood and the intensity of all the analysed psychosomatic symptoms (p<0.001). Conclusion: PTS is related to obesity and is linked to higher serum catecholamines. There were improvements in hormonal abnormalities and psychosomatic symptoms with the given pharmacological treatments.

Keywords

• premenstrual tension syndrome backache abdominal bloating
• headache serum adrenaline noradrenaline
• royal vitamin g vitazinc