Nature Communications (Feb 2020)

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

  • Shin Yen Chong,
  • Sam Cutler,
  • Jing-Jer Lin,
  • Cheng-Hung Tsai,
  • Huai-Kuang Tsai,
  • Sue Biggins,
  • Toshio Tsukiyama,
  • Yi-Chen Lo,
  • Cheng-Fu Kao

DOI
https://doi.org/10.1038/s41467-020-14595-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Transcription-replication conflicts (TRC) can contribute to genome instability. Here the authors reveal that under replication stress H3K4 methylation can play a role in TRC prevention.