Nature Communications (Aug 2016)
SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion
- Eunkyung Lie,
- Ji Seung Ko,
- Su-Yeon Choi,
- Junyeop Daniel Roh,
- Yi Sul Cho,
- Ran Noh,
- Doyoun Kim,
- Yan Li,
- Hyeyeon Kang,
- Tae-Yong Choi,
- Jungyong Nam,
- Won Mah,
- Dongmin Lee,
- Seong-Gyu Lee,
- Ho Min Kim,
- Hyun Kim,
- Se-Young Choi,
- Ji Won Um,
- Myoung-Goo Kang,
- Yong Chul Bae,
- Jaewon Ko,
- Eunjoon Kim
Affiliations
- Eunkyung Lie
- Department of Biological Sciences, Korea Advanced Institute for Science and Technology
- Ji Seung Ko
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Su-Yeon Choi
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science
- Junyeop Daniel Roh
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science
- Yi Sul Cho
- Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
- Ran Noh
- Center for Cognition and Sociality, Institute for Basic Science
- Doyoun Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science
- Yan Li
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science
- Hyeyeon Kang
- Department of Physiology and BK21 PLUS Project to Medical Sciences, Yonsei University College of Medicine
- Tae-Yong Choi
- Department of Physiology, Seoul National University School of Dentistry
- Jungyong Nam
- Department of Biological Sciences, Korea Advanced Institute for Science and Technology
- Won Mah
- Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
- Dongmin Lee
- Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University
- Seong-Gyu Lee
- Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology
- Ho Min Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology
- Hyun Kim
- Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University
- Se-Young Choi
- Department of Physiology, Seoul National University School of Dentistry
- Ji Won Um
- Department of Physiology and BK21 PLUS Project to Medical Sciences, Yonsei University College of Medicine
- Myoung-Goo Kang
- Center for Cognition and Sociality, Institute for Basic Science
- Yong Chul Bae
- Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
- Jaewon Ko
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Eunjoon Kim
- Department of Biological Sciences, Korea Advanced Institute for Science and Technology
- DOI
- https://doi.org/10.1038/ncomms12328
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Synaptic adhesion molecules regulate synapse development and function by both cis and trans-interactions. Here, Lie et al. show that postsynaptic SALM4 regulates excitatory synapse numbers by cisinhibition of the SALM3-LAR transynaptic interaction.
