Frontiers in Medicine (Jan 2021)

MAC Project—Monitoring Anticoagulant Therapy Observational Study: Rationale and Protocol

  • Giuseppe Camporese,
  • Enrico Bernardi,
  • Cristiano Bortoluzzi,
  • Franco Noventa,
  • Ngoc Vo Hong,
  • Elena Callegari,
  • Sabina Villalta,
  • Chiara Tonello,
  • Michela Nardin,
  • Elena Campello,
  • Luca Spiezia,
  • Paolo Simioni

DOI
https://doi.org/10.3389/fmed.2020.584459
Journal volume & issue
Vol. 7

Abstract

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Real-life studies complement data from registrative trials. Because of the delayed registration of direct oral anticoagulants in Italy, scarce real-life data on such treatments is available for the Italian population. The aim of the MAC project is to collect real-life clinical information in unselected patients given oral anticoagulants for venous thromboembolism, during a 5-year follow-up period. This is a prospective-cohort, multi-center, observational study performed in four Italian centers. The estimated samples size is 4,000 patients. The efficacy outcomes are: incidence of symptomatic recurrent venous thromboembolism and of post-thrombotic syndrome. The safety outcomes are: incidence of major bleeding, clinically relevant non-major bleeding, minor bleeding, serious adverse events, and mortality. The MAC project has the potential to improve our understanding of the epidemiology and of the therapeutic strategies adopted in Italian patients with venous thromboembolism.Clinical Trial Registration: WWW.ClinicalTrials.Gov, identifier: NCT0432939.

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