Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

Junyi Chen; Hanzhi Ni; Zhao Meng; Jing Wang; Xiayang Huang; Yansheng Dong; Chao Sun; Yadan Zhang; Lei Cui; Jian Li; Xueshun Jia; Qingbin Meng; Chunju Li

doi:10.1038/s41467-019-11553-7

Nature Communications (Aug 2019)

Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

Junyi Chen,
Hanzhi Ni,
Zhao Meng,
Jing Wang,
Xiayang Huang,
Yansheng Dong,
Chao Sun,
Yadan Zhang,
Lei Cui,
Jian Li,
Xueshun Jia,
Qingbin Meng,
Chunju Li

Affiliations

Junyi Chen: College of Environmental and Chemical Engineering, Shanghai University
Hanzhi Ni: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Zhao Meng: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Jing Wang: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Xiayang Huang: Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, Shanghai University
Yansheng Dong: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Chao Sun: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Yadan Zhang: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Lei Cui: Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, Shanghai University
Jian Li: Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, Shanghai University
Xueshun Jia: College of Environmental and Chemical Engineering, Shanghai University
Qingbin Meng: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Chunju Li: College of Environmental and Chemical Engineering, Shanghai University

DOI: https://doi.org/10.1038/s41467-019-11553-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

Read online

Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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