Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases

Abstract

Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations have unveiled the function of bromodomain containing protein 4 (BRD4) in manipulating the aging process and driving the emergence and progression of aging-related diseases. Aim of review: This review aims to offer a comprehensive outline of BRD4′s functions involved in the aging process, and potential mechanisms through which BRD4 governs the initiation and progression of various aging-related diseases. Key scientific concepts of review: BRD4 has a fundamental role in regulating the cell cycle, apoptosis, cellular senescence, the senescence-associated secretory phenotype (SASP), senolysis, autophagy, and mitochondrial function, which are involved in the aging process. Several studies have indicated that BRD4 governs the initiation and progression of various aging-related diseases, including Alzheimer's disease, ischemic cerebrovascular diseases, hypertension, atherosclerosis, heart failure, aging-related pulmonary fibrosis, and intervertebral disc degeneration (IVDD). Thus, the evidence from this review supports that BRD4 could be a promising target for managing various aging-related diseases, while further investigation is warranted to gain a thorough understanding of BRD4′s role in these diseases.

Keywords

• BRD4
• Senescence
• Inflammation
• Autophagy
• Aging-related diseases