Preparation of corn glycopeptides and evaluation of their antagonistic effects on alcohol-induced liver injury in rats

Xiao-jie Wang; Xiao-lan Liu; Xi-qun Zheng; Yue Qu; Yan-guo Shi

Journal of Functional Foods (Mar 2020)

Preparation of corn glycopeptides and evaluation of their antagonistic effects on alcohol-induced liver injury in rats

Xiao-jie Wang,
Xiao-lan Liu,
Xi-qun Zheng,
Yue Qu,
Yan-guo Shi

Affiliations

Xiao-jie Wang: Key Laboratory of Food Science and Engineering of Heilongjiang Province, Harbin University of Commerce, Harbin 150076, PR China; Key Laboratory of Corn Deep Processing Theory and Technology of Heilongjiang Province, College of Food and Bioengineering, Qiqihar University, Qiqihar 161006, PR China
Xiao-lan Liu: Key Laboratory of Food Science and Engineering of Heilongjiang Province, Harbin University of Commerce, Harbin 150076, PR China; Key Laboratory of Corn Deep Processing Theory and Technology of Heilongjiang Province, College of Food and Bioengineering, Qiqihar University, Qiqihar 161006, PR China; Corresponding authors at: College of Food Engineering, 138 Tongda Street, Daoli District, Harbin, Heilongjiang Province 150076, PR China (Yan-guo Shi). College of Food and Bioengineering, 42 Wenhua Street, Qiqihar, Heilongjiang Province 161006, PR China (Xiao-lan Liu).
Xi-qun Zheng: Heilongjiang Bayi Agricultural University, Daqing 163319, PR China
Yue Qu: Key Laboratory of Corn Deep Processing Theory and Technology of Heilongjiang Province, College of Food and Bioengineering, Qiqihar University, Qiqihar 161006, PR China
Yan-guo Shi: Key Laboratory of Food Science and Engineering of Heilongjiang Province, Harbin University of Commerce, Harbin 150076, PR China; Corresponding authors at: College of Food Engineering, 138 Tongda Street, Daoli District, Harbin, Heilongjiang Province 150076, PR China (Yan-guo Shi). College of Food and Bioengineering, 42 Wenhua Street, Qiqihar, Heilongjiang Province 161006, PR China (Xiao-lan Liu).

Journal volume & issue: Vol. 66
p. 103776

Abstract

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New glycosylated zein peptides (GZP) were produced by transglutaminase-induced d-glucosamine conjugation onto zein peptides. GZP’s antagonistic effects on alcohol-induced liver injury in rats were evaluated. Compared with the alcohol model group, GZP (250 mg/kg·bw) remarkably increased alcohol dehydrogenase, acetaldehyde dehydrogenase, endogenous antioxidant enzymes activities, and GSH levels in liver, decreased serum triacylglycerol, tumor necrosis factor-α, liver malonaldehyde, reactive oxygen species, and lipopolysaccharide (LPS) levels, and significantly reversed pathological changes in liver tissues. These results indicate that low-dose GZP administration can alleviate alcohol-induced liver injury by accelerating alcohol metabolism, reversing hepatic redox status, and attenuating LPS-mediated inflammation responses. GZP is a potential alcohol metabolism promoter and liver-protective agent.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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