Asian Journal of Transfusion Science (Jan 2020)

Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis

  • Archana Solanki,
  • Ashutosh Singh,
  • Abhishek Chauhan,
  • Tulika Chandra,
  • D Himanshu

DOI
https://doi.org/10.4103/ajts.AJTS_89_19
Journal volume & issue
Vol. 14, no. 2
pp. 203 – 205

Abstract

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We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hence TPE was stopped.

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