F1000Research (Oct 2016)

Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 2; referees: 2 approved]

  • Wim E. Crusio,
  • Esha Dhawan,
  • Elissa J. Chesler,
  • Anna Delprato

DOI
https://doi.org/10.12688/f1000research.9484.2
Journal volume & issue
Vol. 5

Abstract

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In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.

Keywords