Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma

Abstract

Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Methods: Clinical data of these cases, submitted to São Paulo State University (UNESP) and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin-eosin and histologically evaluated. Survival analysis was performed, and prognostic value of the presence of lymphatic invasion and the treatment used was determined. Results: Dogs with neoplastic lymphatic vessel invasion had lower overall survival compared with those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared with animals that received carboplatin in addition to surgery. Conclusions: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.

Keywords

• dog
• transitional cell carcinoma
• prognosis
• bladder cancer