KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

Anqi Geng; Runxiang Qiu; Kiyohito Murai; Jiancheng Liu; Xiwei Wu; Heying Zhang; Henry Farhoodi; Nam Duong; Meisheng Jiang; Jiing-kuan Yee; Walter Tsark; Qiang Lu

doi:10.1038/s41467-018-05152-1

Nature Communications (Jul 2018)

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

Anqi Geng,
Runxiang Qiu,
Kiyohito Murai,
Jiancheng Liu,
Xiwei Wu,
Heying Zhang,
Henry Farhoodi,
Nam Duong,
Meisheng Jiang,
Jiing-kuan Yee,
Walter Tsark,
Qiang Lu

Affiliations

Anqi Geng: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Runxiang Qiu: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Kiyohito Murai: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Jiancheng Liu: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Xiwei Wu: Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope
Heying Zhang: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Henry Farhoodi: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Nam Duong: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope
Meisheng Jiang: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles
Jiing-kuan Yee: Department of Virology, Beckman Research Institute of the City of Hope
Walter Tsark: Transgenic/Knockout Mice Facility, Beckman Research Institute of the City of Hope
Qiang Lu: Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope

DOI: https://doi.org/10.1038/s41467-018-05152-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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