Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects

Md Tariqul Haque Tuhin; Dengpan Liang; Fang Liu; Hala Aldawod; Toufiq Ul Amin; Joshua S. Ho; Rasha Emara; Arjun D. Patel; Melanie A. Felmlee; Miki S. Park; James A. Uchizono; Mamoun M. Alhamadsheh

doi:10.1038/s41467-022-31342-z

Nature Communications (Jun 2022)

Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects

Md Tariqul Haque Tuhin,
Dengpan Liang,
Fang Liu,
Hala Aldawod,
Toufiq Ul Amin,
Joshua S. Ho,
Rasha Emara,
Arjun D. Patel,
Melanie A. Felmlee,
Miki S. Park,
James A. Uchizono,
Mamoun M. Alhamadsheh

Affiliations

Md Tariqul Haque Tuhin: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Dengpan Liang: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Fang Liu: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Hala Aldawod: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Toufiq Ul Amin: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Joshua S. Ho: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Rasha Emara: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Arjun D. Patel: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Melanie A. Felmlee: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Miki S. Park: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
James A. Uchizono: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific
Mamoun M. Alhamadsheh: Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific

DOI: https://doi.org/10.1038/s41467-022-31342-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The current peripherally acting mu-opioid receptor antagonists present limited permeability and pharmacokinetic properties. Here, the authors develop a drug delivery approach based on AG10, which demonstrates the impact of mu-opioid receptors in the central nervous system in precipitating opioid-induced constipation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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