Frontiers in Psychiatry (Jun 2024)

Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder

  • Kenta Kato,
  • Hirofumi Tomiyama,
  • Keitaro Murayama,
  • Taro Mizobe,
  • Akira Matsuo,
  • Nami Nishida,
  • Kou Matukuma,
  • Mingi Kang,
  • Kenta Sashikata,
  • Kazufumi Kikuchi,
  • Osamu Togao,
  • Tomohiro Nakao

DOI
https://doi.org/10.3389/fpsyt.2024.1399062
Journal volume & issue
Vol. 15

Abstract

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BackgroundHoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear.MethodsA total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels.ResultsIn patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms.ConclusionsAlthough the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.

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