Advances in Pharmacological Sciences (Jan 2012)

Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis: Emerging Role of Gamma-Glutamyltransferase

  • Etienne Mokondjimobe,
  • Benjamin Longo-Mbenza,
  • Jean Akiana,
  • Ulrich Oswald Ndalla,
  • Regis Dossou-Yovo,
  • Joseph Mboussa,
  • Henri-Joseph Parra

DOI
https://doi.org/10.1155/2012/465634
Journal volume & issue
Vol. 2012

Abstract

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Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods. A prospective followup of 40 adults (21 males; mean age of 34.7±5.8 years) with active PTB on initial phase and continuation phase anti-TB. Results. Only 3% (n=1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0–day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.