Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

Tao Han; Shulong Jiang; Hong Zheng; Qing Yin; Mengyu Xie; Margaret R Little; Xiu Yin; Ming Chen; Su Jung Song; Amer A. Beg; Pier Paolo Pandolfi; Lixin Wan

doi:10.1038/s41467-019-11618-7

Nature Communications (Aug 2019)

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

Tao Han,
Shulong Jiang,
Hong Zheng,
Qing Yin,
Mengyu Xie,
Margaret R Little,
Xiu Yin,
Ming Chen,
Su Jung Song,
Amer A. Beg,
Pier Paolo Pandolfi,
Lixin Wan

Affiliations

Tao Han: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
Shulong Jiang: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
Hong Zheng: Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
Qing Yin: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
Mengyu Xie: Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
Margaret R Little: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
Xiu Yin: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
Ming Chen: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Su Jung Song: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Amer A. Beg: Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Lixin Wan: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute

DOI: https://doi.org/10.1038/s41467-019-11618-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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