Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

Haiyoung Jung; Dong Oh Kim; Jae-Eun Byun; Won Sam Kim; Mi Jeong Kim; Hae Young Song; Young Kwan Kim; Du-Kyeong Kang; Young-Jun Park; Tae-Don Kim; Suk Ran Yoon; Hee Gu Lee; Eun-Ji Choi; Sang-Hyun Min; Inpyo Choi

doi:10.1038/ncomms13674

Nature Communications (Dec 2016)

Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

Haiyoung Jung,
Dong Oh Kim,
Jae-Eun Byun,
Won Sam Kim,
Mi Jeong Kim,
Hae Young Song,
Young Kwan Kim,
Du-Kyeong Kang,
Young-Jun Park,
Tae-Don Kim,
Suk Ran Yoon,
Hee Gu Lee,
Eun-Ji Choi,
Sang-Hyun Min,
Inpyo Choi

Affiliations

Haiyoung Jung: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Dong Oh Kim: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Jae-Eun Byun: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Won Sam Kim: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Mi Jeong Kim: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Hae Young Song: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Young Kwan Kim: Scripps Korea Antibody Institute
Du-Kyeong Kang: Bioenergy and Biochemical Research Center, Korea Research Institute of Bioscience and Biotechnology
Young-Jun Park: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Tae-Don Kim: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Suk Ran Yoon: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Hee Gu Lee: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Eun-Ji Choi: Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine
Sang-Hyun Min: New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Inpyo Choi: Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

DOI: https://doi.org/10.1038/ncomms13674
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The processes regulating the ageing of stem cells are not clearly defined. Here, the authors report that in haematopoietic stem cells (HSC) thioredoxin-interacting protein, known to regulate the cell cycle, binds to p38 mitogen-activated protein kinase and regulates HSC ageing and rejuvenation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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