Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial)

• Jo Carroll,
• Avery B Nathens,
• Damon Scales,
• Keyvan Karkouti,
• Paul T Engels,
• Hans-Peter Hucke,
• Deep Grewal,
• Bruce Schwartz

Affiliations

Jo Carroll

6 Anesthesia, University Health Network, Toronto, Ontario, Canada

Avery B Nathens

Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Damon Scales

clinical associate

Keyvan Karkouti

1 Department of Anesthesia and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada

Paul T Engels

Department of Surgery, McMaster University, Hamilton, Ontario, Canada

Hans-Peter Hucke

5 Ergomed, Center for Data Management and Statistics, Cologne, North Rhine–Westphalia, Germany

Deep Grewal

6 Anesthesia, University Health Network, Toronto, Ontario, Canada

Bruce Schwartz

7 Research and Development, Octapharma AG, Lachen, Switzerland