Immune-enhancing effect of fermented soybean food, Cheonggukjang on cyclophosphamide-treated immunosuppressed rat
Hak Yong Lee,
Young Mi Park,
Dong Yeop Shin,
Hai Min Hwang,
Han Na Jeong,
Hyo Yeon Park,
Hee-Jong Yang,
Gwang Su Ha,
Myeong Seon Ryu,
Ji Won Seo,
Do-Youn Jeong,
Jun Sang Bae,
Byeong Soo Kim,
Jae Gon Kim
Affiliations
Hak Yong Lee
INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea
Young Mi Park
INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea; Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea
Dong Yeop Shin
INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea; Department of Integrated Life Science and Technology, Kongju National University, 32439, Republic of Korea
Hai Min Hwang
INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea
Han Na Jeong
INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea
Hyo Yeon Park
INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea
Hee-Jong Yang
Microbial Institute for Fermentation Industry (MIFI), Sunchang, 56048, Republic of Korea
Gwang Su Ha
Microbial Institute for Fermentation Industry (MIFI), Sunchang, 56048, Republic of Korea
Myeong Seon Ryu
Microbial Institute for Fermentation Industry (MIFI), Sunchang, 56048, Republic of Korea
Ji Won Seo
Microbial Institute for Fermentation Industry (MIFI), Sunchang, 56048, Republic of Korea
Do-Youn Jeong
Microbial Institute for Fermentation Industry (MIFI), Sunchang, 56048, Republic of Korea
Jun Sang Bae
Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea
Byeong Soo Kim
Department of Integrated Life Science and Technology, Kongju National University, 32439, Republic of Korea; Corresponding author.
Cheonggukjang (CGJ) is a traditional food, made by the fermentation of beans, and it has different recipes for different regions in Korea. However, it has anti-inflammatory, anti-cancer, and anti-obesity effects, and is known to affect changes in the intestinal microbiota. In this study, we investigated the immune-enhancing effects of four type CGJs (one commercial and three transitional CGJs). In the cyclophosphamide (CP)-treated immunosuppressed rat, oral administration of CGJs for 4 weeks was used to investigate weight of body and immune organ, change of microbiota, blood and serum parameters, inflammation pathways (MAPKs and NFκB) and histology of spleen. It showed an immunity-enhancing effect through increase Bacteroidetes in gut, the recovery of complete blood count, levels of cytokines and IgG, activation of inflammatory pathways, and histology of spleen. In conclusion, these results show that the intake of a commercial brand CGJ, and traditional CGJs can maintain or promote the body's immunity.
