Therapeutics and Clinical Risk Management (Jul 2021)

Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage

  • Cai Y,
  • Zhuang YK,
  • Wu XY,
  • Dong XQ,
  • Du Q,
  • Yu WH,
  • Wang KY,
  • Hu W,
  • Zheng YK

Journal volume & issue
Vol. Volume 17
pp. 717 – 726

Abstract

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Yong Cai,1 Yao-Kun Zhuang,1 Xiao-Yu Wu,1 Xiao-Qiao Dong,2 Quan Du,2 Wen-Hua Yu,2 Ke-Yi Wang,2 Wei Hu,3 Yong-Ke Zheng3 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, People’s Republic of China; 2Department of Neurosurgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of China; 3Department of Intensive Care Unit, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of ChinaCorrespondence: Xiao-Qiao DongDepartment of Neurosurgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 261 Huansha Road, Hangzhou, 310006, Zhejiang Province, People’s Republic of ChinaEmail [email protected]: Serum hypoxia-inducible factor 1alpha (HIF-1α) is a key regulator in hypoxic and ischemic brain injury. We determined the relationship between serum HIF-1α levels and long-term prognosis plus severity of intracerebral hemorrhage (ICH).Methods: A total of 97 ICH cases and 97 healthy controls were enrolled. Glasgow Coma Scale (GCS) score and hematoma volume were used to assess hemorrhagic severity. Glasgow Outcome Scale (GOS) score of 1– 3 at post-stroke 90 days was defined as a poor outcome.Results: Serum HIF-1α levels of ICH patients were significantly higher than those of healthy controls (median, 218.8 vs 105.4 pg/mL; P 239.4 pg/mL discriminated patients at risk of 90-day poor outcome with sensitivity of 65.9% and specificity of 79.3% (area under the receiver operating characteristic curve, 0.725; 95% confidence interval, 0.625– 0.811; P 239.4 pg/mL were independently associated with a poor 90-day outcome (odds ratio, 5.133; 95% confidence interval, 1.117– 23.593; P=0.036).Conclusion: Serum HIF-1α, in close correlation with hemorrhagic severity and poor 90-day outcome, may serve as a potential prognostic biomarker for ICH.Keywords: intracerebral hemorrhage, prognosis, severity, hypoxia-inducible factor 1alpha

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