A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity

Abstract

5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K i value of 0.445 ± 0.013 µM.

Keywords

• aldose reductase
• thiazolidinedione
• cytotoxicity
• molecular docking