A new genetic variant of dengue serotype 2 virus circulating in the Peruvian Amazon

Francesca Falconi-Agapito; Philippe Selhorst; Xiomara Merino; Fiorella Torres; Johan Michiels; Connie Fernandez; Michael Talledo; Kevin K. Ariën

International Journal of Infectious Diseases (Jul 2020)

A new genetic variant of dengue serotype 2 virus circulating in the Peruvian Amazon

Francesca Falconi-Agapito,
Philippe Selhorst,
Xiomara Merino,
Fiorella Torres,
Johan Michiels,
Connie Fernandez,
Michael Talledo,
Kevin K. Ariën

Affiliations

Francesca Falconi-Agapito: Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium; Unidad de Virología, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 15102, Lima, Peru
Philippe Selhorst: Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium
Xiomara Merino: Unidad de Virología, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 15102, Lima, Peru
Fiorella Torres: Hospital Santa Gema, Yurimaguas, Calle Progreso 405, Yurimaguas, Alto Amazonas, 16501, Loreto, Peru
Johan Michiels: Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium
Connie Fernandez: Hospital Santa Gema, Yurimaguas, Calle Progreso 405, Yurimaguas, Alto Amazonas, 16501, Loreto, Peru
Michael Talledo: Unidad de Virología, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 15102, Lima, Peru
Kevin K. Ariën: Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium; Corresponding author at: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerp, Belgium.

Journal volume & issue: Vol. 96
pp. 136 – 138

Abstract

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We sequenced the envelope gene of dengue virus serotype 2 (DENV-2-E) in samples from an outbreak reported in 2018, in Yurimaguas, Peru. The strain belongs to lineage 2 of the American/Asian genotype. We report a variant with two novel mutations (I379T and V484I) located in domain III of DENV2-E.

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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