Nature Communications (Mar 2019)
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
- Evelyne Lima-Fernandes,
- Alex Murison,
- Tiago da Silva Medina,
- Yadong Wang,
- Anqi Ma,
- Cherry Leung,
- Genna M. Luciani,
- Jennifer Haynes,
- Aaron Pollett,
- Constanze Zeller,
- Shili Duan,
- Antonija Kreso,
- Dalia Barsyte-Lovejoy,
- Bradly G. Wouters,
- Jian Jin,
- Daniel D. De Carvalho,
- Mathieu Lupien,
- Cheryl H. Arrowsmith,
- Catherine A. O’Brien
Affiliations
- Evelyne Lima-Fernandes
- Structural Genomics Consortium, University of Toronto
- Alex Murison
- Princess Margaret Cancer Centre, University Health Network
- Tiago da Silva Medina
- Princess Margaret Cancer Centre, University Health Network
- Yadong Wang
- Princess Margaret Cancer Centre, University Health Network
- Anqi Ma
- Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Cherry Leung
- Princess Margaret Cancer Centre, University Health Network
- Genna M. Luciani
- Structural Genomics Consortium, University of Toronto
- Jennifer Haynes
- Princess Margaret Cancer Centre, University Health Network
- Aaron Pollett
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Constanze Zeller
- Princess Margaret Cancer Centre, University Health Network
- Shili Duan
- Department of Medical Biophysics, University of Toronto
- Antonija Kreso
- Princess Margaret Cancer Centre, University Health Network
- Dalia Barsyte-Lovejoy
- Structural Genomics Consortium, University of Toronto
- Bradly G. Wouters
- Princess Margaret Cancer Centre, University Health Network
- Jian Jin
- Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Daniel D. De Carvalho
- Princess Margaret Cancer Centre, University Health Network
- Mathieu Lupien
- Princess Margaret Cancer Centre, University Health Network
- Cheryl H. Arrowsmith
- Structural Genomics Consortium, University of Toronto
- Catherine A. O’Brien
- Princess Margaret Cancer Centre, University Health Network
- DOI
- https://doi.org/10.1038/s41467-019-09309-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition
