Clinical application of mineralocorticoid receptor antagonists in chronic heart failure

Abstract

The review of literature discusses pathogenetic aspects of chronic heart failure and post-infarction remodelling in the heart. The focus is on the role of neurohormonal activation and the important role of aldosterone. There is data on the efficacy and safety of drugs belonging to mineralocorticoid receptor antagonists obtained in the course of randomized clinical trials. Different aspects of clinical application of the selective aldosterone receptor blocker eplerenone are emphasized. The application in clinical practice is supported by research findings.

Keywords

• хроническая сердечная недостаточность
• инфаркт миокарда
• альдостерон
• антагонисты минералокортикоидных рецепторов
• эплеренон
• chronic heart failure
• myocardial infarction
• aldosterone
• mineralocorticoid receptor antagonists
• eplerenone