Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation: New Catalysts, Substrates and Applications in Total Synthesis
Adnan Ganić,
Denise Rageot,
Lars Tröndlin,
Andreas Pfaltz
Affiliations
Adnan Ganić
SCS-Metrohm Foundation Award for best oral presentation, Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland. [email protected]
Denise Rageot
Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland
Lars Tröndlin
Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland
Andreas Pfaltz
Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland
Iridium-catalyzed asymmetric hydrogenation has emerged as a highly efficient method for the synthesis of enantiomerically pure compounds. This account summarizes our recent efforts in this field. We have developed a new type of P,O-ligand that was successfully applied to the asymmetric hydrogenation of ?,?-unsaturated carbonyl compounds. Furthermore we have demonstrated the potential of known iridium catalysts in the hydrogenation of ?,?-unsaturated boronic esters. And finally we could demonstrate the utility of iridium-catalyzed asymmetric hydrogenation in the formal synthesis of the natural product Platensimycin.
