POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY

Abstract

Aim. To reveal the relation of gene polymorphisms of interleukin-6 (IL6, C174G), interleukin-10 (IL10, C592A), superoxide dismutase (SOD1, G8958A) and angiotensin converting enzyme (ACE, Alu Ins/Del) with postsurgery atrial fibrillation (PSAF) after coronary bypass grafting (CBG) in coronary heart disease patients (CHD).Material and methods. Totally, 80 CHD patients studied, had been admitted for CBG. Genotype assessed for IL6 C174G, IL10 C592A, SOD1 G8958A and ACE Alu Ins/Del. According to PSAF, patients were selected to 2 groups: 1 group — non- PSAF (56 patients, 78,6% males, mean age 61,0±7,5 years), 2 group — with PSAF (24 patients, 83,3% males, mean age 64,7±7,9 years).Results. Analysis of genetic polymorphisms showed the prevalence of СG IL6 C174G (57,2%) genotype, СС IL10 C592A (62,5%), GG SOD1 G8958A (87,5%), I/D ACE Alu Ins/Del (60,8%) among non-arrhythmic patients. In PSAF most prevalent were genotypes СG IL6 C174G (54,2%), СА IL10 C592A (54,2%), GG SOD1 G8958A (79,2%), I/D ACE Alu (58,4%). In multifactor regression analysis, odds ratio for PSAF in allele G IL6 C174G was 1,5 (95% CI, 0,69-3,44, р=0,29), for allele A IL10 C592A — 2,7 (95% CI, 1,2-6,9, р=0,04), for allele A SOD1 G8958A — 2,1 (95% CI, 0,7-6,2, р=0,19), for allele D gene ACE Alu Ins/Del — 0,9 (95% CI, 0,27-3,1, р=0,89).Conclusion. Therefore, presence of allele A of candidate gene IL10 C592A might force the onset of atrial fibrillation during early postsurgery period in coronary bypass.

Keywords

• atrial fibrillation
• coronary bypass
• polymorphism
• genes
• interleukins
• superoxide dismutase
• angiotensine converting enzyme