Nature Communications (May 2016)
The topography of mutational processes in breast cancer genomes
- Sandro Morganella,
- Ludmil B. Alexandrov,
- Dominik Glodzik,
- Xueqing Zou,
- Helen Davies,
- Johan Staaf,
- Anieta M. Sieuwerts,
- Arie B. Brinkman,
- Sancha Martin,
- Manasa Ramakrishna,
- Adam Butler,
- Hyung-Yong Kim,
- Åke Borg,
- Christos Sotiriou,
- P. Andrew Futreal,
- Peter J. Campbell,
- Paul N. Span,
- Steven Van Laere,
- Sunil R. Lakhani,
- Jorunn E. Eyfjord,
- Alastair M. Thompson,
- Hendrik G. Stunnenberg,
- Marc J. van de Vijver,
- John W. M. Martens,
- Anne-Lise Børresen-Dale,
- Andrea L. Richardson,
- Gu Kong,
- Gilles Thomas,
- Julian Sale,
- Cristina Rada,
- Michael R. Stratton,
- Ewan Birney,
- Serena Nik-Zainal
Affiliations
- Sandro Morganella
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Ludmil B. Alexandrov
- Wellcome Trust Sanger Institute
- Dominik Glodzik
- Wellcome Trust Sanger Institute
- Xueqing Zou
- Wellcome Trust Sanger Institute
- Helen Davies
- Wellcome Trust Sanger Institute
- Johan Staaf
- Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University
- Anieta M. Sieuwerts
- Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center
- Arie B. Brinkman
- Department of Molecular Biology, Radboud University, Faculty of Science
- Sancha Martin
- Wellcome Trust Sanger Institute
- Manasa Ramakrishna
- Wellcome Trust Sanger Institute
- Adam Butler
- Wellcome Trust Sanger Institute
- Hyung-Yong Kim
- Department of Pathology, College of Medicine, Hanyang University
- Åke Borg
- Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University
- Christos Sotiriou
- Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles
- P. Andrew Futreal
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Peter J. Campbell
- Wellcome Trust Sanger Institute
- Paul N. Span
- Department of Radiation Oncology, and department of Laboratory Medicine, Radboud university medical center
- Steven Van Laere
- Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Wilrijk, Belgium and Center for Oncological Research, University of Antwerp
- Sunil R. Lakhani
- Centre for Clinical Research and School of Medicine, University of Queensland
- Jorunn E. Eyfjord
- Cancer Research Laboratory, Faculty of Medicine, University of Iceland
- Alastair M. Thompson
- Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center
- Hendrik G. Stunnenberg
- Department of Molecular Biology, Radboud University, Faculty of Science
- Marc J. van de Vijver
- Department of Pathology, Academic Medical Center
- John W. M. Martens
- Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center
- Anne-Lise Børresen-Dale
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Andrea L. Richardson
- Department of Pathology, Brigham and Women's Hospital
- Gu Kong
- Department of Pathology, College of Medicine, Hanyang University
- Gilles Thomas
- Synergie Lyon Cancer, Centre Léon Bérard
- Julian Sale
- MRC Laboratory of Molecular Biology, Francis Crick Avenue
- Cristina Rada
- MRC Laboratory of Molecular Biology, Francis Crick Avenue
- Michael R. Stratton
- Wellcome Trust Sanger Institute
- Ewan Birney
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Serena Nik-Zainal
- Wellcome Trust Sanger Institute
- DOI
- https://doi.org/10.1038/ncomms11383
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Mutational signatures provide evidence of the mechanism of action of a given mutagen and are found in cancer cells. Here, using 560 breast cancer genomes, the authors demonstrate that mutational signatures are frequently associated with genomic architecture including nucleosome positioning and replication timing.
