Nature Communications (Jul 2021)

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

  • Samir Olatunji,
  • Katherine Bowen,
  • Chia-Ying Huang,
  • Dietmar Weichert,
  • Warispreet Singh,
  • Irina G. Tikhonova,
  • Eoin M. Scanlan,
  • Vincent Olieric,
  • Martin Caffrey

DOI
https://doi.org/10.1038/s41467-021-24475-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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In Gram-positive bacteria, lipoprotein intramolecular transacylase Lit produces a lipoprotein variant with less immunogenicity. As such, Lit can be viewed as a virulence factor. Here, structural and functional characterization of the enzyme provides insight into its catalytic mechanism, setting the stage for future studies of Lit as a target for new antibiotics.